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As doctors learn why GLP-1s don't work for about 50% of people, they are also learning more about the complex drivers of obesity. They foresee a future of personalized obesity medicine similar to the way cancer is treated now.

The Justice Department is once again at the center of the news, with investigations of federal lawmakers, the chairman of the Federal Reserve, and resignations by career prosecutors in Minnesota.

Despite dozens of lethal U.S. military strikes on suspected narco-boats, drug flows continue, allies are alarmed, and Caribbean fishermen say their livelihoods are under threat.

The nationwide protests challenging Iran's theocracy appear increasingly smothered a week after authorities shut the country off from the world and escalated a bloody crackdown.

In an unprecedented move, NASA is bringing an astronaut crew home early from the International Space Station because one astronaut has an undisclosed medical condition.

A major winter storm is expected to affect more than 200 million people in the United States this weekend. Freezing rain and ice are a particular concern.

NPR's Ayesha Rascoe speaks to food blogger Adam Gallagher about the dangers of depending on AI for recipe generation.

We found the effects of tariffs and extreme weather, relief (finally!) in the egg cooler, plus one case of shrinkflation.

Harbaugh joins the Giants 11 days after he was fired by the Baltimore Ravens. The Super Bowl champion is now tasked with turning around a beleaguered franchise.

Forty years after the Challenger disaster, NPR explores the engineers' last-minute efforts to stop the launch, their decades of guilt and the vital lessons that remain critical for NASA today.

Prosecutors face multiple challenges in proving Venezuela's Nicolas Maduro played a central role in a cocaine-trafficking conspiracy that spans some two decades.

Today is Apple Pie Day!