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Vice President JD Vance faces a key moment in his career as he heads to Islamabad to negotiate the end of the U.S.-Israeli-led war in Iran.

The fragile ceasefire agreement was tested again on Friday after Iran refused to reopen the Strait of Hormuz. Israel and Hezbollah traded strikes in Lebanon, and Kuwait was attacked with drones.

Local TV giant Nexstar's $6.2 billion deal to acquire rival Tegna won speedy approval from Trump administration regulators. But it faces a tough challenge from a pair of antitrust lawsuits.

The science fiction blockbuster wowed audiences with its depiction of space travel and more. Here's what NASA staff and other scientists say about the basis for the amazing events of the film.

With well over 100 acts on eight stages, almost all of them streaming live, Coachella can be overwhelming. Here's a day-by-day guide to the can't-miss music at the season's biggest musical gathering.

Voice of America staffers are suing Trump administration official Kari Lake, alleging she put pro-Trump propaganda on its airwaves. She has lost numerous rulings of late.

The U.S. has taken custody of an Iranian-flagged cargo ship in the Strait of Hormuz after firing on its engine room, President Trump said in a post on social media.

Anand Giridharadas writes that when Epstein needed friends to rehabilitate him, he knew where to turn: a power elite practiced at disregarding pain.

Drug overdose deaths are plummeting in the U.S. in ways never seen before. Experts worry new, toxic "synthetic" street drugs could derail the recovery.

A special day can be tinged with sorrow when your partner has dementia. But then he found the perfect gift.

U.S. Rep. Eric Swalwell is suspending his campaign for governor of California, as he faces allegations of sexual assault and misconduct.

To discuss what's likely to be next for U.S. military strategy in the Iran war, NPR's Leila Fadel speaks with retired Gen. Joseph Votel.