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How do you manage envy? Can you deal with things ending? Actor-writer-director-producer Mark Duplass tackles the Wild Card question.

Two people who were diagnosed with cancer during childhood describe how the experience interrupted their educations -- and eventually led them to vocations in the medical field as adults.

It's a day of remembrance, mourning and celebration as thousands gather in Rome to pay their respects and say farewell to Pope Francis.

NPR animator and illustrator Jackie Lay tells the story of Victoria Woodhull, who wrote a letter to the New York Herald in 1870 announcing she was running for president — 50 years before women would be allowed to vote.

National Adopt a Shelter Pet Day is on April 30. To bring awareness to the day, the Up First newsletter is sharing some stories from readers about how their pet has impacted their lives.

Do you volunteer or know someone who does? In a new series called "Here to Help," we are sharing stories of people across the U.S. who give back to the community.

Do you volunteer or know someone who does? In a new series called "Here to Help," we are sharing stories of people across the U.S. who give back to the community.

Trump used his time on stage to luxuriate in the crowd's adoration, blame Joe Biden for various national problems, and insist that he, as president, is not getting the credit he deserves.

Outbreaks of the gastrointestinal illness are surging both at sea and on land. Here's what to know.

A number of federal agencies, from HHS to the USDA, have laid off employees only to rescind those terminations days later. An expert says it "suggests something about mismanagement of government."

A group of advocates in Louisville took over an abandoned motel and turned it into a no barrier homeless shelter. It's an approach some say is really needed.

Mother's Day is this weekend. If you haven't figured out what to give to the mothers in your life, we've got you covered.